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KMID : 0605720190250010028
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Journal of the Korean Society of Biological Therapies in Psychiatry
2019 Volume.25 No. 1 p.28 ~ p.35
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The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment
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Son Kyung-Hoon
Seong Su-Jeong
Lee Won-Joon
Hwang Jae-Yeon
Han Jae-Hyun
Jeon Yeong-Ju
Han Chang-Hwan
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Abstract
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Objectives：The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.
Methods：We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulinlike growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIAAA) working group.
Results：When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.
Conclusion：The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
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KEYWORD
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Dementia, Mild cognitive impairment, Aging, Cytokine, Tumor necrosis factor-alpha, Insulin-like growth factor-I, Interleukin-6
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